منابع مشابه
Essential genes of a minimal bacterium.
Mycoplasma genitalium has the smallest genome of any organism that can be grown in pure culture. It has a minimal metabolism and little genomic redundancy. Consequently, its genome is expected to be a close approximation to the minimal set of genes needed to sustain bacterial life. Using global transposon mutagenesis, we isolated and characterized gene disruption mutants for 100 different nones...
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By integrating data from comparative genomics and large-scale deletion studies, we previously proposed a minimal gene set comprising 206 protein-coding genes. To evaluate the consistency of the metabolism encoded by such a minimal genome, we have carried out a series of computational analyses. Firstly, the topology of the minimal metabolism was compared with that of the reconstructed networks f...
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Since the pioneering work by Julius Adler in the 1960's, bacterial chemotaxis has been predominantly studied as metabolism-independent. All available simulation models of bacterial chemotaxis endorse this assumption. Recent studies have shown, however, that many metabolism-dependent chemotactic patterns occur in bacteria. We hereby present the simplest artificial protocell model capable of perf...
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Chemotaxis is vital cellular movement in response to environmental chemicals. Unlike the canonical chemotactic pathway in Escherichia coli, Rhodobacter sphaeroides has both transmembrane and cytoplasmic sensory clusters, with the latter possibly interacting with essential components in the electron transport system. However, the effect of the cytoplasmic sensor and the mechanism of signal integ...
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Objectives: Different treatment approaches have been introduced for children with Speech Sound Disorders (SSD). Minimal pair intervention, Metaphon therapy, and parents and children together approach as linguistically-based approaches are routinely utilized in this population and both of them shared minimal pairs as a common component. The purpose of the current study was to develop and investi...
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ژورنال
عنوان ژورنال: eLife
سال: 2019
ISSN: 2050-084X
DOI: 10.7554/elife.36842